Halide perovskite solar cells (PSCs) have emerged as a promising photovoltaic technology for sustainable energy solutions because of their impressive power conversion efficiency and a path to be manufactured by low-cost, high-throughput methods. To reach PSCs' full potential for practical implementation, it is crucial to solve the issues related to long-term operational stability. Given that PSCs consist of many layers of dissimilar materials which form multiple internal interfaces, it is prudent to examine whether there exist interfacial interactions, most importantly between transport layers and perovskite absorbers, that can trigger instability and affect device performance. In this Perspective, we bring to the attention of the PSC research community the lesser-known interfacial degradation of halide perovskites promoted by contact with metal oxide transport layers and highlight the deleterious effects on the PSCs' performance and stability. We also discuss various mitigation strategies that have shown promise for achieving high-performing and stable PSCs.