Abstract
Multimodal nanotherapeutic cancer treatments are widely studied but are often limited by their costly and complex syntheses that are not easily scaled up. Herein, a simple formulation of glucose-oxidase-coated CuS nanoparticles was demonstrated to be highly effective for melanoma treatment, acting through a synergistic combination of glucose starvation, photothermal therapy, and synergistic advanced chemodynamic therapy enabled by near-infrared irradiation coupled with Fenton-like reactions that were enhanced by endogenous chloride.
Keywords:
Fenton reaction; cancer therapy; copper sulfide nanoparticles; glucose oxidase; starvation therapy.
MeSH terms
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Animals
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / radiation effects
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Antineoplastic Agents / therapeutic use*
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Cell Line, Tumor
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Combined Modality Therapy
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Copper / chemistry
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Copper / radiation effects
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Copper / therapeutic use*
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Drug Therapy
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Enzymes, Immobilized / chemistry
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Enzymes, Immobilized / therapeutic use
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Glucose / chemistry
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Glucose / metabolism
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Glucose Oxidase / chemistry
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Glucose Oxidase / therapeutic use*
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Humans
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Light
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Male
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Melanoma / drug therapy*
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Mice
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Mice, Inbred BALB C
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Mice, Nude
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Nanocomposites / chemistry
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Nanocomposites / radiation effects
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Nanocomposites / therapeutic use*
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Photothermal Therapy
Substances
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Antineoplastic Agents
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Enzymes, Immobilized
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Copper
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Glucose Oxidase
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Glucose
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cupric sulfide