Abstract
The COVID-19 pandemic has created many challenges in the management of immune thrombocytopenic purpura (ITP). The recommendation for avoidance of steroids by WHO led to the off-licence use, supported by NHS England, of thrombopoietin mimetics (TPO-RA) for newly diagnosed or relapsed ITP. This is a real-world prospective study which investigated the treatment patterns and outcomes in this setting. Twenty-four hospitals across the UK submitted 343 cases. Corticosteroids remain the mainstay of ITP treatment, but TPO-RAs were more effective. Incidental COVID-19 infection was identified in a significant number of patients (9·5%), while 14 cases were thought to be secondary to COVID-19 vaccination.
Keywords:
COVID; coronavirus disease 2019; immune thrombocytopenia; platelets; thrombocytopenia.
© 2021 British Society for Haematology and John Wiley & Sons Ltd.
Publication types
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Multicenter Study
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Observational Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Adrenal Cortex Hormones / administration & dosage
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Adrenal Cortex Hormones / adverse effects
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Adrenal Cortex Hormones / therapeutic use
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Adult
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Aged
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Aged, 80 and over
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Autoimmune Diseases / complications
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COVID-19 / blood
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COVID-19 / epidemiology*
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COVID-19 Vaccines / adverse effects
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Combined Modality Therapy
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Comorbidity
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Connective Tissue Diseases / complications
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Contraindications, Drug
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Disease Management
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Female
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Hemorrhage / epidemiology
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Hemorrhage / etiology
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Hospitals, District / statistics & numerical data
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Humans
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Immunoglobulins, Intravenous / therapeutic use
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Immunosuppressive Agents / therapeutic use
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Male
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Middle Aged
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Neoplasms / complications
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Off-Label Use
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Pandemics*
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Platelet Transfusion
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Prospective Studies
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Purpura, Thrombocytopenic, Idiopathic / drug therapy
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Purpura, Thrombocytopenic, Idiopathic / epidemiology
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Purpura, Thrombocytopenic, Idiopathic / etiology
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Purpura, Thrombocytopenic, Idiopathic / therapy*
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Tertiary Care Centers / statistics & numerical data
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Thromboembolism / epidemiology
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Thromboembolism / etiology
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Thrombopoietin / agonists
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Tranexamic Acid / therapeutic use
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Treatment Outcome
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United Kingdom / epidemiology
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Young Adult
Substances
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Adrenal Cortex Hormones
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COVID-19 Vaccines
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Immunoglobulins, Intravenous
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Immunosuppressive Agents
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Tranexamic Acid
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Thrombopoietin