Treatment of Recurrent Undifferentiated Pleomorphic Sarcoma of Infratemporal Fossa by Surgery Combined With Carbon Ion Radiotherapy: One Case Report

Zaixing Wang; Zhiyuan Tang; Hailiang Zhao; Xianhai Zeng; Xiaodong Han; Qiuhang Zhang

doi:10.3389/fsurg.2021.693774

Treatment of Recurrent Undifferentiated Pleomorphic Sarcoma of Infratemporal Fossa by Surgery Combined With Carbon Ion Radiotherapy: One Case Report

Front Surg. 2021 Aug 10:8:693774. doi: 10.3389/fsurg.2021.693774. eCollection 2021.

Authors

Zaixing Wang¹, Zhiyuan Tang¹, Hailiang Zhao¹, Xianhai Zeng¹, Xiaodong Han¹, Qiuhang Zhang²

Affiliations

¹ Institute of ENT and Shenzhen Key Laboratory of ENT, Longgang ENT Hospital, Shenzhen, China.
² Center of Skull Base Surgery, China INN and Department of Otolaryngology-Head and Neck Surgery, Xuanwu Hospital, Capital Medical University, Beijing, China.

Abstract

We retrospectively analyzed the diagnosis and treatment process of one patient with recurrent undifferentiated pleomorphic sarcoma (UPS) of infratemporal fossa and made a definite diagnosis by combining the imaging and pathological examination results. After treatment failure with 2 cycles of chemotherapy and several surgeries, UPS was eventually treated by surgery + carbon ion radiotherapy, and MRI reexamination showed no relapse. Head and neck UPS is located deeply, easily recurs after operation, and difficult to be resected completely by surgery, with a gradually shortened interval of relapse over the number of surgeries, which becomes a treatment challenge. After the last surgery, the patient received carbon ion radiotherapy, with a good therapeutic effect, and no sign of relapse just before sending this article. Based on the above advantages, we have concluded that surgery + carbon ion radiotherapy is a new effective pathway to treat head and neck UPS.

Keywords: infratemporal fossa; operation combined with carbon-ion radiotherapy; otolaryngology head and neck surgery; recurrent; undifferentiated pleomorphic sarcoma.