Objective: The purpose of this study was to investigate the characteristics of viral pathogen spectrum and the epidemiological characteristics of each viral pathogen in hospitalized cases associated with severe acute respiratory infection (SARI) in Luohe City, Henan Province from 2017 to 2019. Methods: Based the SARI Case Surveillance Platform, SARI cases were collected in Central Hospital of Luohe City, Henan Province from November 2017 to February 2019. In the end, 783 SARI cases were included, whose throat swabs were taken within 24 h of admission, as well as their demographic characteristics, onset time, clinical characteristics and other information recorded. At the same time, viral identification was performed, and the age and time distribution of each virus were analyzed. Results: The age of 783 SARI cases shown as M (P25, P75) was 3 (1, 5) years old, ranging from 1 month to 95 years old. Children under 5 years old were the majority (71.01%). The males (61.81%) were more than females (38.18%). Among the 783 SARI cases, a total of 9 kind of viruses were identified with 64.88% (508/783) of the throat swabs tested positive for at least one virus. The positive rate of influenza virus and human respiratory syncytial virus were both 20.18% (158 cases), which was the highest among all the detected respiratory virus. The co-infection rate was 15.84% (124/783), among which double infection was the most common, accounting for 85.48% (106/124) of the co-infected cases. And human respiratory syncytial virus, human rhinovirus and influenza virus were the most common pathogen in co-infection cases. Moreover, the viral positive rate was 68.71% in children aged 5 years and 63.27% in people aged 60-95 years. Influenza and human respiratory syncytial virus dominated in winter and spring, while human parainfluenza virus was the main infection in summer. Conclusion: Influenza virus and human respiratory syncytial virus were the main viruses in throat swabs of SARI cases from 2017 to 2019 in Luohe City, Henan Province. There were differences in the age and seasonal epidemiological characteristics of each virus.
目的： 了解2017—2019年河南省漯河市住院严重急性呼吸道感染病例（SARI）的病毒性病原谱特征。 方法： 通过“SARI病例监测平台”，收集2017年11月到2019年2月河南省漯河市中心医院的SARI病例。最终纳入783例SARI病例，所有病例在入院24 h内采集咽拭子，并记录人口学特征、发病时间、临床特点等信息，同时进行病毒检测和鉴定，并分析不同年龄和时间SARI病例的病毒检出情况。 结果： 783例SARI病例年龄M（P25，P75）为3（1，5）岁，范围为1月龄~95岁，以<5岁儿童为主（71.01%）；男性（61.81%）多于女性（38.18%）。783份SARI病例咽拭子标本中，共有64.88%（508/783）咽拭子标本检出至少1种病毒，共检出9种病毒。流感病毒、人呼吸道合胞病毒检出率较高，均为20.18%（158例）。各病毒混合感染率达15.84%（124/783），其中双重感染最常见，占混合感染病例的85.48%（106/124）；混合感染病例中主要以人呼吸道合胞病毒、人鼻病毒、人流感病毒最常见。<5岁儿童与60~95岁老人两个年龄组病毒检出率较高，分别为68.71%和63.27%。冬春季以流感和人呼吸道合胞病毒感染为主，夏季以人副流感病毒感染为主。 结论： 2017—2019年河南省漯河市SARI病例咽拭子标本以流感病毒和人呼吸道合胞病毒为主要病毒，各病毒的流行特征存在年龄和时间差异。.