hiPSC-Derived Cells as Models for Drug Discovery

Rivka Ofir

doi:10.3390/ijms22168626

hiPSC-Derived Cells as Models for Drug Discovery

Int J Mol Sci. 2021 Aug 11;22(16):8626. doi: 10.3390/ijms22168626.

Author

Rivka Ofir¹

Affiliation

¹ BGU-iPSC Core Facility, The Regenerative Medicine & Stem Cell (RMSC) Research Center, Ben Gurion University of the Negev, Be'er Sheva 84105, Israel.

Abstract

More than 85% of pre-clinically tested drugs fail during clinical trials, which results in a long, inefficient and costly process, suggesting that animal models are often poor predictors of human biology [...].

Publication types

Editorial
Introductory Journal Article

MeSH terms

Animals
Cell Culture Techniques
Cell Differentiation
Cells, Cultured
Drug Discovery / methods*
Drug Discovery / trends
Drug Evaluation, Preclinical / methods
Humans
Induced Pluripotent Stem Cells / cytology
Induced Pluripotent Stem Cells / physiology*
Models, Biological