Abstract
Within this study, new materials were synthesized and characterized based on polysiloxane modified with different ratios of N-acetyl-l-cysteine (NAC) and crosslinked via UV-assisted thiol-ene addition, in order to obtain efficient membranes able to resist bacterial adherence and biofilm formation. These membranes were subjected to in vitro testing for microbial adherence against S. pneumoniae using standardized tests. WISTAR rats were implanted for 4 weeks with crosslinked siloxane samples without and with NAC. A set of physical characterization methods was employed to assess the chemical structure and morphological aspects of the new synthetized materials before and after contact with the microbiological medium.
Keywords:
N-acetyl-l-cysteine; Streptococcus pneumoniae; antibacterial; cochlear implants.
MeSH terms
-
Acetylcysteine / chemistry
-
Acetylcysteine / pharmacology
-
Acetylcysteine / therapeutic use
-
Animals
-
Anti-Bacterial Agents / chemistry*
-
Anti-Bacterial Agents / pharmacology
-
Anti-Bacterial Agents / therapeutic use
-
Bacterial Adhesion / drug effects
-
Biofilms / drug effects
-
Coated Materials, Biocompatible / chemistry*
-
Coated Materials, Biocompatible / pharmacology
-
Coated Materials, Biocompatible / therapeutic use
-
Cochlear Implants / adverse effects
-
Cochlear Implants / microbiology*
-
Otitis / drug therapy*
-
Polymers / chemistry*
-
Polymers / pharmacology
-
Polymers / therapeutic use
-
Rats
-
Rats, Wistar
-
Siloxanes / chemistry*
-
Siloxanes / pharmacology
-
Siloxanes / therapeutic use
-
Streptococcus pneumoniae / drug effects
-
Sulfhydryl Compounds / chemistry
-
Surface Properties
Substances
-
Anti-Bacterial Agents
-
Coated Materials, Biocompatible
-
Polymers
-
Siloxanes
-
Sulfhydryl Compounds
-
Acetylcysteine