The Diagnosis of Perineural Invasion: A Crucial Factor in Novel Algorithm of Coexistence of Conventional and Nerve-Sparing Radical Hysterectomy

Andrzej Skręt; Joanna Ewa Skręt-Magierło; Mariusz Książek; Bogusław Gawlik; Joanna Bielatowicz; Edyta Barnaś

doi:10.3390/diagnostics11081308

The Diagnosis of Perineural Invasion: A Crucial Factor in Novel Algorithm of Coexistence of Conventional and Nerve-Sparing Radical Hysterectomy

Diagnostics (Basel). 2021 Jul 21;11(8):1308. doi: 10.3390/diagnostics11081308.

Authors

Andrzej Skręt¹, Joanna Ewa Skręt-Magierło², Mariusz Książek³, Bogusław Gawlik¹, Joanna Bielatowicz¹, Edyta Barnaś²

Affiliations

¹ Health Care Center, Department of Obstetrics and Gynecology with Oncological Gynecology, Krakowska 91, 39-200 Dębica, Poland.
² College of Medical Sciences, University of Rzeszow, Rejtana 16c, 35-959 Rzeszów, Poland.
³ Clinical Department of Morphological Sciences, Clinical Provincial Hospital No. 2 St. Jadwiga Krolowej in Rzeszow, Lwowska 60, 35-301 Rzeszów, Poland.

Abstract

Nerve-sparing radical hysterectomy (NSRH) was introduced to mitigate adverse effects associated with conventional radical hysterectomy (CRH) in cervical cancer. However, the introduction of NSRH was compromised by possible existence of perineural invasion (PNI). Additionally, the coexistence of NSRH and CRH is currently the fact. The aim of the study was to review the literature and attempt to construct a novel and preliminary PNI diagnostic algorithm that would establish the coexistence of NSRH and CRH in one system of early-stage cervical cancer (ESCC) surgical treatment. This algorithm takes into account the PNI risk factors and current and future diagnostic methods such as imaging and biopsy.

Keywords: cervical cancer; diagnosis; perineural invasion.