Modeling Extracellular Matrix-Cell Interactions in Lung Repair and Chronic Disease

Tillie Louise Hackett; Emmanuel Twumasi Osei

doi:10.3390/cells10082145

Modeling Extracellular Matrix-Cell Interactions in Lung Repair and Chronic Disease

Cells. 2021 Aug 20;10(8):2145. doi: 10.3390/cells10082145.

Authors

Tillie Louise Hackett^{1

2}, Emmanuel Twumasi Osei^{1

2

3}

Affiliations

¹ Centre for Heart Lung Innovation, St. Paul's Hospital, 1081 Burrard Street, Vancouver, BC V6Z 1Y6, Canada.
² Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.
³ Department of Biology, University of British Columbia, Okanagan, BC V6T 1Z4, Canada.

Abstract

The lung extracellular matrix (ECM) is a complex and dynamic mixture of fibrous proteins (collagen, elastin), glycoproteins (fibronectin, laminin), glycosaminoglycans (heparin, hyaluronic acid) and proteoglycans (perlecan, versican), that are essential for normal lung development and organ health [...].

Publication types

Editorial
Research Support, Non-U.S. Gov't

MeSH terms

Airway Remodeling
Animals
Cell Communication*
Chronic Disease
Extracellular Matrix / metabolism*
Extracellular Matrix Proteins / metabolism*
Humans
Lung / metabolism*
Lung / pathology
Lung Diseases / metabolism*

Substances

Extracellular Matrix Proteins

Abstract

Publication types

MeSH terms

Substances

Grants and funding