Neuroprotective Potential of Mild Uncoupling in Mitochondria. Pros and Cons

Dmitry B Zorov; Nadezda V Andrianova; Valentina A Babenko; Irina B Pevzner; Vasily A Popkov; Savva D Zorov; Ljubava D Zorova; Egor Yu Plotnikov; Gennady T Sukhikh; Denis N Silachev

doi:10.3390/brainsci11081050

Neuroprotective Potential of Mild Uncoupling in Mitochondria. Pros and Cons

Brain Sci. 2021 Aug 8;11(8):1050. doi: 10.3390/brainsci11081050.

Authors

Dmitry B Zorov^{1

2}, Nadezda V Andrianova^{1

3}, Valentina A Babenko^{1

2}, Irina B Pevzner^{1

2}, Vasily A Popkov^{1

2}, Savva D Zorov^{1

3}, Ljubava D Zorova^{1

2}, Egor Yu Plotnikov^{1

2}, Gennady T Sukhikh², Denis N Silachev^{1

2}

Affiliations

¹ Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119991 Moscow, Russia.
² Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, 117997 Moscow, Russia.
³ Faculty of Bioengineering and Bioinformatics, Lomonosov Moscow State University, 119991 Moscow, Russia.

Abstract

There has been an explosion of interest in the use of uncouplers of oxidative phosphorylation in mitochondria in the treatment of several pathologies, including neurological ones. In this review, we analyzed all the mechanisms associated with mitochondrial uncoupling and the metabolic and signaling cascades triggered by uncouplers. We provide a full set of positive and negative effects that should be taken into account when using uncouplers in experiments and clinical practice.

Keywords: brain; mitochondria; neuroprotection; uncoupling.

Publication types

Review

Grants and funding

19-14-00173/the Russian Science Foundation