Spatial scales, patterns, and positivity trends of SARS-CoV-2 pandemics in mass rapid antigen testing in Slovakia

PLoS One. 2021 Aug 25;16(8):e0256669. doi: 10.1371/journal.pone.0256669. eCollection 2021.

Abstract

We study geographical epidemic scales and patterns and positivity trends of SARS-CoV-2 pandemics in mass antigen testing in Slovakia in 2020. The observed test positivity was exponentially distributed with a long scale exponential spatial trend, and its characteristic correlation length was approximately 10 km. Spatial scales also play an important role in test positivity reduction between two consecutive testing rounds. While test positivity decreased in all counties, it increased in individual municipalities with low test positivity in the earlier testing round in a way statistically different from a mean-reversion process. Also, non-residents testing influences the mass testing results as test positivity of non-residents was higher than of residents when testing was offered only in municipalities with the highest positivity in previous rounds. Our results provide direct guidance for pandemic geographical data surveillance and epidemic response management.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antigens, Viral / analysis*
  • COVID-19 / diagnosis*
  • COVID-19 / epidemiology
  • COVID-19 / virology
  • COVID-19 Serological Testing
  • Enzyme-Linked Immunosorbent Assay
  • Humans
  • Pandemics
  • SARS-CoV-2 / isolation & purification
  • SARS-CoV-2 / metabolism*
  • Slovakia / epidemiology

Substances

  • Antigens, Viral

Grants and funding

RK: Slovak Research and Development Agency under the Contract No. APVV-18-0308, RK, KB: Slovak Research and Development Agency under the Contract No. PP-COVID-20-0017, RK, KB: Scientific Grant Agency of the Slovak Republic under the Grants No. 1/0755/19, RK, KB: Scientific Grant Agency of the Slovak Republic under the Grants No. 1/0521/20.