IRF4 L116R mutation promotes proliferation of chronic lymphocytic leukemia B cells inducing MYC

Hematol Oncol. 2021 Dec;39(5):707-711. doi: 10.1002/hon.2915. Epub 2021 Aug 25.
No abstract available

Keywords: IRF4 L116R mutation; MYC; chronic lymphocytic leukemia; proliferation.

Publication types

  • Case Reports
  • Letter

MeSH terms

  • Aged
  • Biomarkers, Tumor / genetics
  • Biomarkers, Tumor / metabolism*
  • Cell Proliferation*
  • Cohort Studies
  • Follow-Up Studies
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Interferon Regulatory Factors / genetics*
  • Interferon Regulatory Factors / metabolism
  • Leukemia, Lymphocytic, Chronic, B-Cell / genetics
  • Leukemia, Lymphocytic, Chronic, B-Cell / metabolism
  • Leukemia, Lymphocytic, Chronic, B-Cell / pathology*
  • Male
  • Mutation*
  • Prognosis
  • Proto-Oncogene Proteins c-myc / genetics
  • Proto-Oncogene Proteins c-myc / metabolism*
  • Tumor Cells, Cultured

Substances

  • Biomarkers, Tumor
  • Interferon Regulatory Factors
  • MYC protein, human
  • Proto-Oncogene Proteins c-myc
  • interferon regulatory factor-4