Hepatocellular Carcinoma in a Patient With Crohn's Disease

Akira Hokama; Shingo Arakaki; Shinichiro Ishino; Yutaka Nakagawa; Souhei Tabata; Daiki Agarie; Satoshi Kuwae; Ryuta Zukeyama; Tatsuji Maeshiro; Yuma Tsuruta; Akiko Matsuzaki; Naoki Wada; Mitsuhisa Takatsuki; Jiro Fujita

doi:10.7759/cureus.16570

Hepatocellular Carcinoma in a Patient With Crohn's Disease

Cureus. 2021 Jul 22;13(7):e16570. doi: 10.7759/cureus.16570. eCollection 2021 Jul.

Authors

Affiliations

¹ Department of Endoscopy, Graduate School of Medicine, University of the Ryukyus, Nishihara, JPN.
² Department of Infectious, Respiratory, and Digestive Medicine, Graduate School of Medicine, University of the Ryukyus, Nishihara, JPN.
³ Department of General and Digestive Surgery, Graduate School of Medicine, University of the Ryukyus, Nishihara, JPN.
⁴ Department of Pathology, University of the Ryukyus Hospital, Nishihara, JPN.
⁵ Department of Pathology and Oncology, Graduate School of Medicine, University of the Ryukyus, Nishihara, JPN.

Abstract

A 44-year-old woman with a 26-year history of Crohn's disease (CD) presented with intermittent fever, vomiting, and watery diarrhea. Her medication included an elemental diet, mesalazine, and infliximab. Liver profile and viral hepatitis markers were normal. Computed tomography scans showed a hepatic tumor by chance. Serum tumor markers disclosed elevated protein induced by vitamin K absence-II. With a diagnosis of hepatocellular carcinoma (HCC), she underwent a hepatic resection of the tumor, revealing well-to-moderately differentiated HCC. The nontumor region of the liver disclosed the absence of cirrhosis or other diseases. Here, the development of HCC in CD without underlying liver diseases is discussed with a review of the literature.

Keywords: computed tomography; crohn’s disease (cd); hepatocellular carcinoma; infliximab; pathology.

Publication types

Case Reports