A single-sided magnet for deep-depth fat quantification

Ya Wang; Yajie Xu; Mingkang Zhang; Temitope Emmanuel Komolafe; Weiqian Wang; Hai Luo; Xiao Chen; Xiaodong Yang; Ziyue Wu

doi:10.1016/j.jmr.2021.107053

A single-sided magnet for deep-depth fat quantification

J Magn Reson. 2021 Oct:331:107053. doi: 10.1016/j.jmr.2021.107053. Epub 2021 Aug 13.

Authors

Ya Wang¹, Yajie Xu², Mingkang Zhang³, Temitope Emmanuel Komolafe¹, Weiqian Wang⁴, Hai Luo⁴, Xiao Chen⁴, Xiaodong Yang⁵, Ziyue Wu⁶

Affiliations

¹ Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou 215163, Jiangsu, China; School of Biomedical Engineering (Suzhou), Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230026, China.
² Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou 215163, Jiangsu, China.
³ Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou 215163, Jiangsu, China; School of Electronic and Information Engineering, Changchun University of Science and Technology, 130022, Changchun, China.
⁴ Wuxi Marvel Stone Healthcare Co. Ltd., Wuxi 214135, Jiangsu, China.
⁵ Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou 215163, Jiangsu, China. Electronic address: xiaodong.yang@sibet.ac.cn.
⁶ Wuxi Marvel Stone Healthcare Co. Ltd., Wuxi 214135, Jiangsu, China. Electronic address: iyue.wu@marvelstonemed.com.

PMID: 34428727
DOI: 10.1016/j.jmr.2021.107053

Abstract

Early detection of fatty-liver disease is important before further aggravations of the disease, such as cirrhosis, can develop. In this study, we developed a low-cost, movable single-sided magnet for in vivo liver fat quantification. A gradient field of 73.5 G/cm and a field strength of 0.0725 T were obtained by structurally optimizing the concave U-shaped magnet, on which the region of interest (ROI) was a curved shape about 0.4 mm thick, 8 cm above the surface of the radiofrequency (RF) coil. We constructed a prototype nuclear magnetic-resonance (NMR) relaxometry system based on this optimized magnet. Subsequent phantom experiments demonstrated the effectiveness of the single-sided magnet in evaluating different proton density fat fraction (PDFF) phantoms. As expected, the results of the six phantoms showed good positive correlation between PDFF and the fitted fat amplitude, which suggested that single-sided NMR relaxometry could be used to quantify liver fat in vivo.

Keywords: Liver fat quantification; Movable; NMR relaxometry; Single-sided magnet.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adipose Tissue / diagnostic imaging
Liver / diagnostic imaging
Magnetic Resonance Imaging*
Magnetic Resonance Spectroscopy
Magnets*
Phantoms, Imaging