Converging technologies: targeting the hallmarks of cancer using ultrasound and microbubbles

Janith Wanigasekara; Andressa Maria Aguiar de Carvalho; Patrick J Cullen; Brijesh Tiwari; James F Curtin

doi:10.1016/j.trecan.2021.07.004

Converging technologies: targeting the hallmarks of cancer using ultrasound and microbubbles

Trends Cancer. 2021 Oct;7(10):886-890. doi: 10.1016/j.trecan.2021.07.004. Epub 2021 Aug 20.

Authors

Janith Wanigasekara¹, Andressa Maria Aguiar de Carvalho¹, Patrick J Cullen², Brijesh Tiwari³, James F Curtin⁴

Affiliations

¹ BioPlasma Research Group, School of Food Science and Environmental Health, Technological University Dublin, Dublin, Ireland; Department of Food Biosciences, Teagasc Food Research Centre, Ashtown, Dublin, Ireland; Environmental Sustainability & Health Institute (ESHI), Technological University Dublin, Dublin, Ireland.
² BioPlasma Research Group, School of Food Science and Environmental Health, Technological University Dublin, Dublin, Ireland; University of Sydney, School of Chemical and Biomolecular Engineering, Sydney, Australia.
³ Department of Food Biosciences, Teagasc Food Research Centre, Ashtown, Dublin, Ireland.
⁴ BioPlasma Research Group, School of Food Science and Environmental Health, Technological University Dublin, Dublin, Ireland; Environmental Sustainability & Health Institute (ESHI), Technological University Dublin, Dublin, Ireland; FOCAS Research Institute, Technological University Dublin, Dublin, Ireland. Electronic address: james.curtin@tudublin.ie.

PMID: 34426143
DOI: 10.1016/j.trecan.2021.07.004

Abstract

Various complex biological effects occur when ultrasonic compression waves travel through biological material. The myriad of biological outcomes instigated by ultrasound are evident when viewed through the lens of the hallmarks of cancer. Herein, we summarise the therapeutic potential of ultrasound, enhanced by microbubbles, for the treatment of cancer.

Keywords: cancer; hallmarks; microbubbles; targeted therapy; ultrasound.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Humans
Microbubbles*
Neoplasms* / diagnostic imaging
Neoplasms* / therapy
Ultrasonic Waves