Modulation of immune response in Ebola virus disease

Goutam Banerjee; Kamal Shokeen; Nilanjan Chakraborty; Saumya Agarwal; Arindam Mitra; Sachin Kumar; Pratik Banerjee

doi:10.1016/j.coph.2021.07.004

Modulation of immune response in Ebola virus disease

Curr Opin Pharmacol. 2021 Oct:60:158-167. doi: 10.1016/j.coph.2021.07.004. Epub 2021 Aug 20.

Authors

Goutam Banerjee¹, Kamal Shokeen², Nilanjan Chakraborty³, Saumya Agarwal¹, Arindam Mitra⁴, Sachin Kumar⁵, Pratik Banerjee⁶

Affiliations

¹ Department of Food Science and Human Nutrition, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA.
² Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, Assam, 781039, India.
³ Department of Microbiology, Adamas University, Kolkata, West Bengal, 700126, India.
⁴ Department of Microbiology, Adamas University, Kolkata, West Bengal, 700126, India. Electronic address: arindam.mitra@adamasuniversity.ac.in.
⁵ Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, Assam, 781039, India. Electronic address: sachinku@iitg.ac.in.
⁶ Department of Food Science and Human Nutrition, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA. Electronic address: pratik@illinois.edu.

PMID: 34425392
DOI: 10.1016/j.coph.2021.07.004

Abstract

Ebola virus disease targets and destroys immune cells, including macrophages and dendritic cells, leading to impairment of host response. After infection, a combination of strategies including alteration and evasion of immune response culminating in a strong inflammatory response can lead to multi-organ failure and death in most infected patients. This review discusses immune response dynamics, mainly focusing on how Ebola manipulates innate and adaptive immune responses and strategizes to thwart host immune responses. We also discuss the challenges and prospects of developing therapeutics and vaccines against Ebola.

Keywords: Ebola; Filoviruses; Immune evasion; Interferons; Pathogenicity.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Ebolavirus*
Hemorrhagic Fever, Ebola*
Humans
Immunity, Innate
Macrophages