Yap Promotes Noncanonical Wnt Signals From Cardiomyocytes for Heart Regeneration

Circ Res. 2021 Oct;129(8):782-797. doi: 10.1161/CIRCRESAHA.121.318966. Epub 2021 Aug 23.

Abstract

[Figure: see text].

Keywords: CRISPR-Cas systems; Wnt signaling pathway; extracellular matrix; fibrosis; myocardial infarction.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cells, Cultured
  • Humans
  • Mice
  • Mice, Inbred C57BL
  • Myocardial Infarction / metabolism*
  • Myocardial Infarction / pathology
  • Myocytes, Cardiac / metabolism*
  • Myocytes, Cardiac / physiology
  • Myofibroblasts / metabolism
  • Receptors, G-Protein-Coupled / genetics
  • Receptors, G-Protein-Coupled / metabolism*
  • Regeneration*
  • Wnt Proteins / genetics
  • Wnt Proteins / metabolism
  • Wnt Signaling Pathway
  • YAP-Signaling Proteins / genetics
  • YAP-Signaling Proteins / metabolism*

Substances

  • Gpr177 protein, mouse
  • Receptors, G-Protein-Coupled
  • Wnt Proteins
  • YAP-Signaling Proteins
  • Yap1 protein, mouse