Withanolides from Physalis angulata L

R Ya Okmanov; M M Makhmudova; I D Bobaev; B Tashkhodjaev

doi:10.1107/S205698902100709X

Withanolides from Physalis angulata L

Acta Crystallogr E Crystallogr Commun. 2021 Jul 16;77(Pt 8):804-808. doi: 10.1107/S205698902100709X. eCollection 2021 Aug 1.

Authors

R Ya Okmanov¹, M M Makhmudova¹, I D Bobaev^{1

2}, B Tashkhodjaev¹

Affiliations

¹ S.Yunusov Institute of the Chemistry of Plant Substances Academy of Sciences, of Uzbekistan 100170, Mirzo Ulugbek Str., 77, Tashkent, Uzbekistan.
² Tashkent Chemical-Technological Institute, of Uzbekistan 100011, A. Navoiy Str., 32, Tashkent, Uzbekistan.

Abstract

The compounds (17S,20R,22R,24R,25S)-5β,6β:20,24-diep-oxy-4β,25-dihy-droxy-1-oxowith-2-en-26,22-olide and (20R,22R)-5α,14α,20-Trihy-droxy-1-oxo-6α,7α-ep-oxy-witha-2-enolide were isolated from a chloro-form extract of the aerial parts of Physalis angulata L. (Solanaceae). Two products were isolated from the chromatographic separation extract. Compound I corresponds to physangulide B chloro-form monosolvate, C₂₈H₃₈O₇·CHCl₃, while compound II is 14α-hy-droxy-ixocarpanolide, C₂₈H₄₀O₇. In the two mol-ecular structures, the conformation of the steroid part (rings A, B, C, D) does not differ. In both crystals, mol-ecules are linked by inter-molecular O-H⋯O hydrogen bonds along the c-axis direction and form a two-dimensional network parallel to the ac plane. The absolute configuration was determined from X-ray diffraction data.

Keywords: 14α-hydroxyixocarpanolide; Physalis angulata L.; chloroform solvate; crystal structure; hydrogen bonding; molecular structure; physangulide B.