A meta-analysis of Cryptosporidium species in humans from southern Africa (2000-2020)

Kehinde Foluke Omolabi; Paul Olalekan Odeniran; Mahmoud E Soliman

doi:10.1007/s12639-021-01436-4

A meta-analysis of Cryptosporidium species in humans from southern Africa (2000-2020)

J Parasit Dis. 2022 Mar;46(1):304-316. doi: 10.1007/s12639-021-01436-4. Epub 2021 Aug 18.

Authors

Kehinde Foluke Omolabi¹, Paul Olalekan Odeniran², Mahmoud E Soliman¹

Affiliations

¹ Molecular Bio-Computation and Drug Design Laboratory, School of Health Sciences, University of KwaZulu-Natal, Westville Campus, Durban, 4001 South Africa.
² Department of Veterinary Parasitology and Entomology, Faculty of Veterinary Medicine, University of Ibadan, Ibadan, Nigeria.

Abstract

Abstract: The epidemiology of cryptosporidiosis in southern Africa is largely unknown. The disease is associated with diarrhea and nutritional deficiencies, leading to severe morbidity and mortality among immune-compromised patients. This study aimed to assess the pooled prevalence of Cryptosporidium spp. infection among immune-compromised humans in southern Africa over the past 20 years. Reports of Cryptosporidium spp. infection in humans published between 2000 and 2020 using Google Scholar, PubMed, Ovid Medline, African Journal Online (AJOL), and Web of Science literature databases were obtained. Inclusion criteria of sorted articles for Cryptosporidium spp. infection were standardized using preferred reporting items for systematic reviews and meta-analyses (PRISMA) checklist. A total of 22 eligible studies were sorted for meta-analysis. Overall prevalence of Cryptosporidium spp. infection in southern African countries with reports was 16.8% (95% CI 9.7-25.3). Sub-group analysis showed a pooled prevalence of 25.2, 20.5, and 17.9% among HIV/AIDS patients, children, and diarrhoeic individuals, respectively. Pooled prevalence was highest in South Africa and lowest in Zimbabwe across examined individuals. The pooled prevalence of Cryptosporidium spp. infections in diarrhoeic patients was highest in individuals from Botswana (17.6%) which is significantly different (Χ ² = 9.337; P = 0.002) from South Africans (12.7%). South African individuals with HIV/AIDS showed the highest pooled prevalence of Cryptosporidium infections than other countries. The high prevalence of Cryptosporidium spp. infections among immune-compromised patients in southern Africa showed that the pathogen is of significant importance in this region. Continuous studies on the genetic characterization of Cryptosporidium spp. isolates and associated risk factors are needed across southern Africa to identify the predominant subtypes in humans.

Supplementary information: The online version contains supplementary material available at 10.1007/s12639-021-01436-4.

Keywords: Cryptosporidiosis; HIV; Prevalence; Protozoa; Public health; Zoonotic disease.

Publication types

Review