Carrageenan gel beads for echinochrome inclusion: Influence of structural features of carrageenan

Irina M Yermak; Vladimir I Gorbach; Ivan A Karnakov; Viktoria N Davydova; Evgeniya A Pimenova; Dmitry А Chistyulin; Vladimir V Isakov; Valery P Glazunov

doi:10.1016/j.carbpol.2021.118479

Carrageenan gel beads for echinochrome inclusion: Influence of structural features of carrageenan

Carbohydr Polym. 2021 Nov 15:272:118479. doi: 10.1016/j.carbpol.2021.118479. Epub 2021 Jul 27.

Authors

Irina M Yermak¹, Vladimir I Gorbach², Ivan A Karnakov², Viktoria N Davydova², Evgeniya A Pimenova³, Dmitry А Chistyulin², Vladimir V Isakov², Valery P Glazunov²

Affiliations

¹ G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of the Russian Academy of Sciences, 100 Let Vladivostoku Prosp. 159, 690022 Vladivostok, Russian Federation. Electronic address: imyer@mail.ru.
² G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of the Russian Academy of Sciences, 100 Let Vladivostoku Prosp. 159, 690022 Vladivostok, Russian Federation.
³ A.V. Zhirmunsky National Scientific Center of Marine Biology, Far-Eastern Branch of the Russian Academy of Sciences, Palchevskogo ul. 17, 690041, Russian Federation.

PMID: 34420738
DOI: 10.1016/j.carbpol.2021.118479

Abstract

Carrageenan (CRG) and carrageenan/chitosan (CH) gel beads (CRG/CH) were prepared as a release delivery system for echinochrome A (Ech). According to spectral data, the Ech was dispersed in the polymer matrix, interacted with CRG, was not oxidised, and remained stable after encapsulation in CRG beads. Carrageenan beads containing Ech were coated with CH by layering. The influence of the structural features of CRG on the formation of beads and the beads morphology, swelling behaviour, mucoadhesive properties and drug release were evaluated. The polysaccharide matrices with Ech showed different swelling characteristics depending on the pH of the medium and the structure of the CRG used. The slow drug release from polysaccharide matrixes was observed for κ- and κ/β-CRG beads, that contained 3,6-anhydro-α-d-galactopyranose units and had high molecular weight. The obtained results showed the prospects of using polysaccharide beads to include Ech.

Keywords: Carrageenan; Chitosan; Delivery system; Fluorescently labeled chitosan; Mucoadhesive; SEM; Spectroscopy (IR, UV).

MeSH terms

Carrageenan*
Chitosan*
Drug Liberation*

Substances

Carrageenan
Chitosan