EXPLORing exosomes for the treatment of acute kidney injury

Eibhlin Goggins; Shinji Tanaka

doi:10.1016/j.kint.2021.05.039

EXPLORing exosomes for the treatment of acute kidney injury

Kidney Int. 2021 Sep;100(3):508-510. doi: 10.1016/j.kint.2021.05.039.

Authors

Eibhlin Goggins¹, Shinji Tanaka²

Affiliations

¹ Division of Nephrology and Center for Immunity, Inflammation, and Regenerative Medicine, University of Virginia, Charlottesville, Virginia, USA.
² Division of Nephrology and Center for Immunity, Inflammation, and Regenerative Medicine, University of Virginia, Charlottesville, Virginia, USA. Electronic address: st3ff@virginia.edu.

PMID: 34420658
DOI: 10.1016/j.kint.2021.05.039

Abstract

Exosomes are emerging as a novel drug delivery system for the treatment of numerous diseases, including acute kidney injury. In this issue of Kidney International, Kim et al. use a novel optogenetically engineered exosome technology, "EXPLOR," to deliver the exosomal repressor of nuclear factor-κB into mice before and after renal ischemia-reperfusion. They report that these exosomes downregulated renal nuclear factor-κB signaling and ameliorated acute kidney injury. This study deserves attention for its significant scientific and potential clinical value in acute kidney injury.

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MeSH terms

Acute Kidney Injury* / therapy
Animals
Exosomes*
Kidney
Mice
NF-kappa B
Reperfusion Injury*

Substances

NF-kappa B