In light of the recent result of the muon g-2 experiment and the update on the test of lepton flavor universality R_{K} published by the LHCb Collaboration, we systematically study for the first time a set of models with minimal field content that can simultaneously give (i) a thermal dark matter candidate; (ii) large loop contributions to b→sℓℓ processes able to address R_{K} and the other B anomalies; (iii) a natural solution to the muon g-2 discrepancy through chirally enhanced contributions. Moreover, this type of model with heavy particles and chiral enhancement can evade the strong limits from direct searches but can be tested at present and future colliders and direct-detection searches.