Population genetic analysis of 12 X-chromosomal STRs in a Swiss sample

Michel Bottinelli; Alexandre Gouy; Silvia Utz; Martin Zieger

doi:10.1007/s00414-021-02684-y

Population genetic analysis of 12 X-chromosomal STRs in a Swiss sample

Int J Legal Med. 2022 Mar;136(2):561-563. doi: 10.1007/s00414-021-02684-y. Epub 2021 Aug 22.

Authors

Michel Bottinelli¹, Alexandre Gouy², Silvia Utz³, Martin Zieger⁴

Affiliations

¹ Laboratorio di Diagnostica Molecolare, Via G. Petrini 2, 6900, Lugano, Switzerland.
² Gouy Data Consulting, Sentier de Renges 4A, 1026, Denges, Switzerland.
³ Institute of Forensic Medicine, Forensic Molecular Biology Department, University of Bern, Sulgenauweg 40, 3007, Bern, Switzerland.
⁴ Institute of Forensic Medicine, Forensic Molecular Biology Department, University of Bern, Sulgenauweg 40, 3007, Bern, Switzerland. Martin.Zieger@irm.unibe.ch.

Abstract

X-chromosomal STRs are a powerful tool to assess a broad variety of complex kinship scenarios. We introduce herewith the first Swiss X-STR dataset based on 1198 individuals (592 female, 606 male), characterized with the Qiagen Investigator® Argus X-12 QS multiplex kit. Anomalous allele patterns, allele and haplotype frequencies, and forensic and population genetic parameters are presented. We detected linkage disequilibrium within three out of the four designated linkage groups and no apparent intra-national population substructure. We compared the dataset to a global panel of X-STR datasets and it fits well in the European context, as expected.

Keywords: Forensics; Kinship; Population data; Switzerland; X-STR.

MeSH terms

Chromosomes, Human, X
DNA Fingerprinting
Female
Gene Frequency
Genetics, Population*
Haplotypes
Humans
Male
Microsatellite Repeats*
Switzerland