Carbon nanotubes as an emerging nanocarrier for the delivery of doxorubicin for improved chemotherapy

Abstract

Carbon nanotubes (CNTs), a versatile nanocarrier for doxorubicin (DOX) delivery had attracted significant attention in drug delivery of pharmaceuticals. Several properties such as high surface area, high drug loading capacity, stability, ease of functionalization, ultrahigh length to diameter ratio and good cellular uptake make them preferred nanocarrier as multipurpose drug delivery system. Several surface properties of CNTs can be easily modified by covalent/noncovalent functionalization, which can make CNTs a profound nanomaterial. Hydrophobic surface of CNTs facilitated π-π stacking interactions, with several drugs and therapeutic agents having aromatic ring in their structure, for example anthracyclines. In case some drug molecules, electrostatic interaction between drug and CNTs comes into the picture. DOX, an anthracycline anticancer drug, can easily adsorb on the surface of CNTs by π-π stacking interactions. In present article, we have reviewed various CNTs based drug delivery systems for the delivery of DOX alone or in combination with genetic materials and other drug molecules. In addition, we described recent updates in CNTs based drug delivery system for the delivery of DOX, we covered adsorption and desorption, different types of functionalization, to alter the properties of CNTs in vitro and in vivo. CNT attached many targeting ligands for the targeted delivery of DOX have also been discussed.

Keywords: Cancer; Carbon nanotube; Doxorubicin; Drug delivery; Functionalization.