Establishment of induced pluripotent stem cells from schizophrenia discordant fraternal twins

Yuichiro Yada; Mika Suga; Ran Shibukawa; Yukako Sagara; Yasue Okanishi; Takako Enami; Kayoko Tsukita; Takayuki Kondo; Keiko Imamura; Genichi Sugihara; Toshiya Murai; Haruhisa Inoue

doi:10.1016/j.scr.2021.102504

Establishment of induced pluripotent stem cells from schizophrenia discordant fraternal twins

Stem Cell Res. 2021 Aug:55:102504. doi: 10.1016/j.scr.2021.102504. Epub 2021 Aug 14.

Authors

Affiliations

¹ iPSC-based Drug-Discovery and Development Team, RIKEN BioResource Research Center, Kyoto, Japan; Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan.
² iPSC-based Drug-Discovery and Development Team, RIKEN BioResource Research Center, Kyoto, Japan.
³ Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan; Medical-risk Avoidance Based on iPS Cells Team, RIKEN Center for Advanced Intelligence Project (AIP), Kyoto, Japan.
⁴ iPSC-based Drug-Discovery and Development Team, RIKEN BioResource Research Center, Kyoto, Japan; Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan; Medical-risk Avoidance Based on iPS Cells Team, RIKEN Center for Advanced Intelligence Project (AIP), Kyoto, Japan.
⁵ Department of Psychiatry, Kyoto University Graduate School of Medicine, Kyoto, Japan.
⁶ iPSC-based Drug-Discovery and Development Team, RIKEN BioResource Research Center, Kyoto, Japan; Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan; Medical-risk Avoidance Based on iPS Cells Team, RIKEN Center for Advanced Intelligence Project (AIP), Kyoto, Japan. Electronic address: haruhisa.inoue@riken.jp.

PMID: 34419750
DOI: 10.1016/j.scr.2021.102504

Abstract

Schizophrenia (SCZ) is one of the major psychiatric disorders. The genetic factor is certainly influential in the onset of the disease but is not decisive. There is no identified molecular/cellular marker of the disease, and the pathomechanism is still unknown. In this study, we generated human induced pluripotent stem cells (iPSCs) derived from SCZ-discordant fraternal twins, and they could contribute to elucidation of the pathomechanism of SCZ.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Humans
Induced Pluripotent Stem Cells*
Schizophrenia* / genetics
Twins, Dizygotic