Practicable Applications of Aggregation-Induced Emission with Biomedical Perspective

Yuqing Wang; Bozhang Xia; Qianqian Huang; Ting Luo; Yuanyuan Zhang; Peter Timashev; Weisheng Guo; Fangzhou Li; Xing-Jie Liang

doi:10.1002/adhm.202100945

Practicable Applications of Aggregation-Induced Emission with Biomedical Perspective

Adv Healthc Mater. 2021 Dec;10(24):e2100945. doi: 10.1002/adhm.202100945. Epub 2021 Aug 21.

Authors

Yuqing Wang^{1

2

3}, Bozhang Xia^{1

2}, Qianqian Huang^{1

2

3}, Ting Luo^{4

5}, Yuanyuan Zhang⁶, Peter Timashev⁶, Weisheng Guo⁷, Fangzhou Li¹, Xing-Jie Liang^{1

2}

Affiliations

¹ CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, Beijing, 100190, China.
² University of Chinese Academy of Sciences, Beijing, 100049, China.
³ Sino-Danish Center for Education and Research, Sino-Danish College of University of Chinese Academy of Sciences, Beijing, 100049, China.
⁴ School of Medicine, Nankai University, Tianjin, 300071, China.
⁵ Department of Interventional Ultrasound, Chinese PLA General Hospital, Beijing, 100853, China.
⁶ Laboratory of Clinical Smart Nanotechnologies, Institute for Regenerative Medicine, Sechenov University, Moscow, 119991, Russia.
⁷ Translational Medicine Center, Key Laboratory of Molecular Target and Clinical Pharmacology, School of Pharmaceutical Sciences and The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, 510260, China.

PMID: 34418321
DOI: 10.1002/adhm.202100945

Abstract

Considerable efforts have been made into developing aggregation-induced emission fluorogens (AIEgens)-containing nano-therapeutic systems due to the excellent properties of AIEgens. Compared to other fluorescent molecules, AIEgens have advantages including low background, high signal-to-noise ratio, good sensitivity, and resistance to photobleaching, in addition to being exempt from concentration quenching or aggregation-caused quenching effects. The present review outlines the major developments in the biomedical applications of AIEgens-containing systems. From a literature survey, the recent AIE works are reviewed and the reasons why AIEgens are chosen in various biomedical applications are highlighted. The research activities on AIEgens-containing systems are increasing rapidly, therefore, the present review is timely.

Keywords: aggregation-induced emission; biomedical applications; detection; diagnosis; therapies.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Fluorescent Dyes*
Signal-To-Noise Ratio

Substances

Fluorescent Dyes