Partners with a killer: Metabolic signaling promotes inflammatory cell death

Zhonghua Liu; Tsan Sam Xiao

doi:10.1016/j.cell.2021.07.036

Partners with a killer: Metabolic signaling promotes inflammatory cell death

Cell. 2021 Aug 19;184(17):4374-4376. doi: 10.1016/j.cell.2021.07.036.

Authors

Zhonghua Liu¹, Tsan Sam Xiao²

Affiliations

¹ Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA.
² Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA. Electronic address: tsx@case.edu.

Abstract

In this issue of Cell, Evavold et al. (2021) report that mTOR Complex 1 (mTORC1), a metabolic signaling complex, controls reactive oxygen species (ROS) production in mitochondria, which in turn promotes inflammatory cell death mediated by gasdermin D (GSDMD). This provides a new mechanistic connection between metabolic signaling and inflammatory cell death.

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

Cell Death
Intracellular Signaling Peptides and Proteins*
Phosphate-Binding Proteins
Pyroptosis*
Signal Transduction

Substances

Intracellular Signaling Peptides and Proteins
Phosphate-Binding Proteins

Abstract

Publication types

MeSH terms

Substances

Grants and funding