Anti-Golgi Antibody as a Potential Indicator for Rheumatoid Arthritis

Lab Med. 2022 Mar 7;53(2):156-160. doi: 10.1093/labmed/lmab046.

Abstract

Objective: To reveal the relationship between anti-Golgi antibody (AGA) and clinical diseases through retrospective analysis.

Methods: The clinical data of 584 cases testing positive for AGA in the past 11 years were collected and retrospectively analyzed.

Results: AGA pattern accounted for .2% of positive ANA results. In total, 35.0% of diagnosed patients had autoimmune diseases (AID), mainly rheumatoid arthritis (RA). High-titer AGA (≧1:1000) was common in AID. In nondiagnosed patients with clinical symptoms, joint pain/muscle pain was the most common.

Conclusions: Positive AGA with high titer was closely related to RA. Joint pain/muscle pain was the most common symptom in patients who tested AGA positive. Therefore, AGA may be a key indicator of RA in the Chinese population.

Keywords: anti-Golgi antibody; antibody titer; antinuclear antibodies; autoimmune diseases; disease progression; rheumatoid arthritis.

MeSH terms

  • Arthritis, Rheumatoid* / diagnosis
  • Arthritis, Rheumatoid* / epidemiology
  • Autoantibodies
  • Autoimmune Diseases*
  • Humans
  • Retrospective Studies

Substances

  • Autoantibodies