Two amide glycosides from Portulaca oleracea L. and its bioactivities

Nat Prod Res. 2021 Aug;35(16):2655-2659. doi: 10.1080/14786419.2019.1660333. Epub 2019 Sep 5.

Abstract

Two novel amide glycosides, named oleraciamide E (1) and oleraciamide F (2), were isolated from the Portulaca oleracea L. Their structures were determined by means of 1D and 2D NMR spectroscopic and UHPLC-ESI-TOF-MS methods. Oleraciamide E (1) exhibited anticholinesterase activity with IC50 values of 52.43 ± 0.33 μM, and presented scavenging activity in 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical quenching assay, with the IC50 values of 24.64 ± 0.33 μM.

Keywords: Portulaca oleracea L.; amide glycosides; anticholinesterase activity; antioxidant activity.

MeSH terms

  • Amides* / isolation & purification
  • Amides* / pharmacology
  • Free Radical Scavengers* / isolation & purification
  • Free Radical Scavengers* / pharmacology
  • Glycosides* / isolation & purification
  • Glycosides* / pharmacology
  • Molecular Structure
  • Phytochemicals / isolation & purification
  • Phytochemicals / pharmacology
  • Portulaca* / chemistry
  • Spectrometry, Mass, Electrospray Ionization

Substances

  • Amides
  • Free Radical Scavengers
  • Glycosides
  • Phytochemicals