Modeling schizophrenia with iPS cell technology and disease mouse models

Abstract

Induced pluripotent stem cell (iPSC) technology, which enables the direct analysis of neuronal cells with the same genetic background as patients, has recently garnered significant attention in schizophrenia research. This technology is important because it enables a comprehensive interpretation using mice and human clinical research and cross-species verification. Here I review recent advances in modeling schizophrenia using iPSC technology, alongside the utility of disease mouse models.

Keywords: Disease mouse model; Molecular pathology; Schizophrenia; Translational research; iPS cells.