Primetime for microglia: When stress and infection collide

Alexis M Ceasrine; Staci D Bilbo

doi:10.1016/j.neuron.2021.07.023

Primetime for microglia: When stress and infection collide

Neuron. 2021 Aug 18;109(16):2503-2505. doi: 10.1016/j.neuron.2021.07.023.

Authors

Alexis M Ceasrine¹, Staci D Bilbo²

Affiliations

¹ Department of Psychology and Neuroscience, Duke University, Durham, NC 27710, USA.
² Department of Psychology and Neuroscience, Duke University, Durham, NC 27710, USA; Department of Neurobiology, Duke University, Durham, NC 27710, USA. Electronic address: staci.bilbo@duke.edu.

PMID: 34411536
DOI: 10.1016/j.neuron.2021.07.023

Abstract

Inflammation during critical windows of development contributes to behavioral affect later in life. In this of Neuron, Cao et al. (2021) demonstrate a novel mechanism through which early life Tlr4-dependent inflammation in microglia permanently alters neuronal function and leaves male mice susceptible to stress-induced depressive-like behaviors.

Publication types

Comment

MeSH terms

Animals
Inflammation*
Male
Mice
Microglia*
Neurons