Three dimensional radial echo planar imaging for functional MRI

Abstract

Purpose: To demonstrate a novel 3D radial echo planar imaging (3D REPI) sequence for flexible, rapid, and motion-robust sampling in fMRI.

Methods: The 3D REPI method expands on the recently described golden angle rotated EPI trajectory using radial batched internal navigator echoes (TURBINE) approach by exploiting the unused perpendicular direction in the EPI readout to form fast analogues of rotated stack of stars or spirals trajectories that cover all 3 dimensions of k-space. An iterative conjugate gradient algorithm with SENSE reconstruction and time-segmented non-uniform fast Fourier transform (FFT) was used for parallel imaging acceleration and to account for the effects of B₀ inhomogeneity. The golden angle rotation allowed for sliding window reconstruction schemes to be applied in brain BOLD fMRI experiments.

Results: Combined whole brain visual and motor fMRI experiments were successfully carried out on a clinical 3T scanner at 2 mm isotropic and 1 × 1 × 2 mm³ resolutions using the 3D REPI design. Improved sampling characteristics and image quality were observed for twisted trajectories at the expense of prolonged readout times and off-resonance effects. The ability to correct for rigid motion correction was also demonstrated.

Conclusions: 3D REPI presents a flexible approach for segmented volumetric fMRI with motion correction and high in-plane spatial resolutions. Improved BOLD fMRI brain activation maps were obtained using a sliding window reconstruction.

Keywords: 3D radial imaging; echo planar imaging; functional MRI.