Lymphadenopathy and granulomas: benignancy of malignancy and differential diagnosis with endobronchial ultrasound-transbronchial needle biopsy 19G needle fine-needle aspiration biopsy

Paul Zarogoulidis; Dimitris Hatzibougias; Kosmas Tsakiridis; Dimitris Matthaios; Wolfgang Hohenforst-Schmidt; Haidong Huang; Chong Bai; Stavros Tryfon; Maria Saroglou; Bojan Zaric; Ioannis Boujkovinas; Chrisanthi Karapantzou

doi:10.2217/lmt-2021-0002

Lymphadenopathy and granulomas: benignancy of malignancy and differential diagnosis with endobronchial ultrasound-transbronchial needle biopsy 19G needle fine-needle aspiration biopsy

Lung Cancer Manag. 2021 May 26;10(3):LMT49. doi: 10.2217/lmt-2021-0002. eCollection 2021 Sep.

Authors

Affiliations

¹ 3 University Surgery Department, AHEPA University General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.
² Pulmonary Department, 'Bioclinic' Private Clinic, Thessaloniki, Greece.
³ Microdiagnostics Private Pathology Laboratory, Thessaloniki, Greece.
⁴ Thoracic Surgery Department, 'Interbalkan' European Medical Center, Thessaloniki, Greece.
⁵ Oncology Department, General Hospital of Rhodos, Rhodos, Greece.
⁶ Department of Cardiology/Pulmonology/Intensive Care/Nephrology, Sana Clinic Group Franken, 'Hof' Clinics, University of Erlangen, Hof, Germany.
⁷ Department of Respiratory & Critical Care Medicine, Changhai Hospital, The Second Military Medical University, Shanghai, PR China.
⁸ Pulmonary Department (NHS), 'G Papanikolaou' General Hospital, Thessaloniki, Greece.
⁹ Faculty of Medicine, University of Novi Sad, Institute for Pulmonary Diseases of Vojvodina, Novi Sad, Serbia.
¹⁰ Oncology Department, 'Bioclinic' Private Clinic, Thessaloniki, Greece.
¹¹ Ear, Nose & Throat (ENT) Department, Ludwig-Maximilians University of Munich, Munich, Germany.

Abstract

Endobronchial ultrasound (EBUS) is a very useful tool for the diagnosis of lymphadenopathy of the mediastinum. Nowadays, EBUS can substitute video-assisted thoracic surgery when a 19G needle is used. Several studies have provided data for efficient diagnosis not only for lung cancer, but for also sarcoidosis, tuberculosis and lymphoma. We present five cases of EBUS-transbronchial needle biopsy 19G needle used for the diagnosis of mediastinum lymphadenopathy. We present not only the pathological diagnosis, but also the steps for the differential clinical and pathological differential diagnosis for sarcoidosis, tuberculosis, cancer metastasis, respiratory infection and lymphoma.

Keywords: EBUS; lymphoma; sarcoidodis; tuberculosis.

Publication types

Case Reports