White Matter Hyperintensities of Bilateral Lenticular Putamen in Patients with Proliferative Diabetic Retinopathy: A Voxel-based Morphometric Study

Ang Xiao; Qian-Min Ge; Hui-Feng Zhong; Li-Juan Zhang; Hui-Ye Shu; Rong-Bin Liang; Yi Shao; Qiong Zhou

doi:10.2147/DMSO.S321270

White Matter Hyperintensities of Bilateral Lenticular Putamen in Patients with Proliferative Diabetic Retinopathy: A Voxel-based Morphometric Study

Diabetes Metab Syndr Obes. 2021 Aug 12:14:3653-3665. doi: 10.2147/DMSO.S321270. eCollection 2021.

Authors

Ang Xiao^#¹, Qian-Min Ge^#¹, Hui-Feng Zhong², Li-Juan Zhang¹, Hui-Ye Shu¹, Rong-Bin Liang¹, Yi Shao¹, Qiong Zhou¹

Affiliations

¹ Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Jiangxi Province Ocular Disease Clinical Research Center, Nanchang, Jiangxi, 330006, People's Republic of China.
² Department of Intensive Care, The First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, 341000, People's Republic of China.

^# Contributed equally.

Abstract

Objective: To explore the changes in gray matter volume (GMV) and white matter volume (WMV) in proliferative diabetic retinopathy (PDR) patients using voxel-based morphometry (VBM).

Participants and methods: In total, 15 patients (10 males, 5 females) with PDR were enrolled to the patient group and 15 healthy controls (10 males, 5 females) to the control group, matched for age, sex, handedness, and education status. All individuals underwent voxel-based morphometry scans. GMV and WMV were compared between the two groups.

Results: GMV in bilateral superior temporal gyrus, sixth area of left cerebellum, left middle temporal gyrus, left orbital inferior frontal gyrus and left middle cingulum gyrus and WMV in left thalamus and left precuneus were significantly lower in patients than controls (P<0.01). Conversely, WMV was significantly higher in bilateral lenticular putamen of patients than controls (P<0.01).

Conclusion: Abnormal GMV and WMV in many specific areas of the cerebrum provide new insights for exploration of the occurrence and development of DR and its pathophysiology.

Keywords: gray matter; proliferative diabetic retinopathy; voxel-based morphometric; white matter.

Grants and funding

The Central Government Guides Local Science and Technology Development Foundation (No: 20211ZDG02003); Key Research Foundation of Jiangxi Province (No: 20181BBG70004, 20203BBG73059); Excellent Talents Development Project of Jiangxi Province (No: 20192BCBL23020); Natural Science Foundation of Jiangxi Province (No: 20181BAB205034); Grassroots Health Appropriate Technology “Spark Promotion Plan” Project of Jiangxi Province (No: 20188003); Health Development Planning Commission Science Foundation of Jiangxi Province (No: 20201032, 202130210); Health Development Planning Commission Science TCM Foundation of Jiangxi Province (No: 2018A060, 2020A0087); Education Department Foundation of Jiangxi Province(No: GJJ200157, GJJ200159, GJJ200169); and Key Research Foundation of Jiangxi Province (grant no. 20203BBG73058).