Psychiatric symptoms as initial manifestation in neuromyelitis optica spectrum disorder without cortical lesions: A report of two cases

J Neuroimmunol. 2021 Oct 15:359:577693. doi: 10.1016/j.jneuroim.2021.577693. Epub 2021 Aug 12.

Abstract

Diagnosing neuromyelitis optica spectrum disorder (NMOSD) remains a challenge, especially in patients with atypical presentations. Here, we describe two NMOSD patients who initially presented psychiatric symptoms without cortical lesions. This report expands our understanding of the possible presentations of NMOSD. Knowledge of rare initial symptoms may allow timely diagnosis and early therapeutic intervention, preventing more severe attacks affecting the spinal cord or eyes.

Keywords: Aquaporin-4 antibody; Autoimmune encephalitis; Neuromyelitis optica spectrum disorder; Psychiatric symptom.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Cerebral Cortex / diagnostic imaging*
  • Diagnosis, Differential
  • Female
  • Glucocorticoids / therapeutic use
  • Humans
  • Male
  • Mental Disorders / diagnostic imaging*
  • Mental Disorders / drug therapy
  • Mental Disorders / psychology*
  • Methylprednisolone / therapeutic use
  • Middle Aged
  • Neuromyelitis Optica / diagnostic imaging*
  • Neuromyelitis Optica / drug therapy
  • Neuromyelitis Optica / psychology*

Substances

  • Glucocorticoids
  • Methylprednisolone