Push-rim wheelchair propulsion frequently causes severe upper limb injuries in people relying on the wheelchair for ambulation. To address this problem, we developed a novel handle-based wheelchair propulsion method that follows a cyclic motion within ergonomic joint ranges of motion. The aim of this study was to measure hand propulsion forces, joint excursions and net joint torques for this novel propulsion device and to compare its performance against traditional push-rim wheelchair propulsion. We hypothesized that under similar conditions, joint excursions of this novel handle-based device will remain within their ergonomic range and that the effectiveness of the propulsion forces will be higher, leading to lower average propulsion forces compared to push-rim propulsion and reducing the risk of injury. Eight paraplegic subjects propelled the new device at two different loads on a custom-made wheelchair-based test rig. Video motion capture and force sensors were used to monitor shoulder and wrist joint kinematics and kinetics. Shoulder and wrist loads were calculated using a modified upper-extremity Wheelchair Propulsion Model available in OpenSim. The results show that with this novel propulsion device joint excursions are within their recommended ergonomic ranges, resulting in a reduced range of motion of up to 30% at the shoulder and up to 80% at the wrist, while average resultant peak forces were reduced by up to 20% compared to push-rim propulsion. Furthermore, the lower net torques at both the shoulder and wrist demonstrate the potential of this novel propulsion system to reduce the risk of upper-extremity injuries.