Activation of circulating platelets in vaccine-induced thrombotic thrombocytopenia and its reversal by intravenous immunoglobulin

James D McFadyen; Prerna Sharma; Mitchell J Moon; Jonathan Noonan; Elizabeth Goodall; Huyen A Tran; Karlheinz Peter

doi:10.1111/bjh.17750

Activation of circulating platelets in vaccine-induced thrombotic thrombocytopenia and its reversal by intravenous immunoglobulin

Br J Haematol. 2022 Jan;196(1):234-237. doi: 10.1111/bjh.17750. Epub 2021 Aug 16.

Authors

James D McFadyen^{1

2

3

4}, Prerna Sharma¹, Mitchell J Moon^{1

4}, Jonathan Noonan^{1

4}, Elizabeth Goodall², Huyen A Tran^{2

3}, Karlheinz Peter^{1

3

4

5}

Affiliations

¹ Atherothrombosis and Vascular Biology, Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia.
² Department of Clinical Hematology, The Alfred Hospital, Melbourne, Victoria, Australia.
³ Department of Medicine, Central Clinical School, Monash University, Melbourne, Victoria, Australia.
⁴ Baker Department of Cardiometabolic Health, University of Melbourne, Melbourne, Victoria, Australia.
⁵ Department of Cardiology, The Alfred Hospital, Melbourne, Victoria, Australia.

No abstract available

Keywords: immunotherapy; platelet activation; platelet aggregation; vaccines.

Publication types

Case Reports
Letter
Research Support, Non-U.S. Gov't

MeSH terms

Biomarkers
Blood Platelets / immunology*
Blood Platelets / metabolism*
COVID-19 Vaccines / adverse effects
Disease Management
Disease Susceptibility
Female
Humans
Immunoglobulins, Intravenous* / therapeutic use
Immunophenotyping
Middle Aged
Platelet Count
Thrombocytopenia / blood
Thrombocytopenia / diagnosis
Thrombocytopenia / etiology*
Thrombocytopenia / therapy*
Treatment Outcome
Vaccines / adverse effects*

Substances

Biomarkers
COVID-19 Vaccines
Immunoglobulins, Intravenous
Vaccines