Bisphenol A-induced DNA damages promote to lymphoma progression in human lymphoblastoid cells through aberrant CTNNB1 signaling pathway

Yin-Kai Chen; Yan-Yan Tan; Min Yao; Ho-Chen Lin; Mon-Hsun Tsai; Yu-Yun Li; Yih-Jen Hsu; Tsung-Tao Huang; Chia-Wei Chang; Chih-Ming Cheng; Chun-Yu Chuang

doi:10.1016/j.isci.2021.102888

Bisphenol A-induced DNA damages promote to lymphoma progression in human lymphoblastoid cells through aberrant CTNNB1 signaling pathway

iScience. 2021 Jul 21;24(8):102888. doi: 10.1016/j.isci.2021.102888. eCollection 2021 Aug 20.

Authors

Yin-Kai Chen¹, Yan-Yan Tan², Min Yao³, Ho-Chen Lin², Mon-Hsun Tsai⁴, Yu-Yun Li², Yih-Jen Hsu⁵, Tsung-Tao Huang⁶, Chia-Wei Chang⁶, Chih-Ming Cheng^{7

8}, Chun-Yu Chuang²

Affiliations

¹ Department of Hematology, National Taiwan University Cancer Center, Taipei, 106, Taiwan.
² Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, 101, section 2, Kuang-Fu Road, Hsinchu, 30013, Taiwan.
³ Division of Hematology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, 100, Taiwan.
⁴ Institute of Biotechnology, National Taiwan University, Taipei, 106, Taiwan.
⁵ Department of Internal Medicine, National Taiwan University Hospital, Taipei, 100, Taiwan.
⁶ Biomedical Platform and Incubation Service Division, Taiwan Instrument Research Institute, National Applied Research Laboratories, Hsinchu, 302, Taiwan.
⁷ Biomedical Technology and Device Research Laboratories, Industrial Technology Research Institute, Hsinchu, 310, Taiwan.
⁸ Mike & Clement TECH Co., Ltd., Changhua Country, Taiwan.

Abstract

Lymphoma is a group of blood cancers that develop from the immune system, and one of the main risk factors is associated with exposure to environmental chemicals. Bisphenol A (BPA) is a common chemical used in the manufacture of materials in polycarbonate and epoxy plastic products and can interfere with the immune system. BPA is considered to possibly induce lymphoma development by affecting the immune system, but its potential mechanisms have not been well established. This study performed a gene-network analysis of microarray data sets in human lymphoma tissues as well as in human cells with BPA exposure to explore module genes and construct the potential pathway for lymphomagenesis in response to BPA. This study provided evidence that BPA exposure resulted in disrupted cell cycle and DNA damage by activating CTNNB1, the initiator of the aberrant constructed CTNNB1-NFKB1-AR-IGF1-TWIST1 pathway, which may potentially lead to lymphomagenesis.

Keywords: cancer; molecular biology.