The emerging role of circular RNAs in spinal cord injury

Peng Peng; Hao Yu; Yongjin Li; Jingyuan Huang; Shengyu Yao; Cong Xing; Weixiao Liu; Bin Zhang; Shiqing Feng

doi:10.1016/j.jot.2021.06.001

The emerging role of circular RNAs in spinal cord injury

J Orthop Translat. 2021 Jul 22:30:1-5. doi: 10.1016/j.jot.2021.06.001. eCollection 2021 Sep.

Authors

Peng Peng^{1

2}, Hao Yu^{1

2}, Yongjin Li^{1

2}, Jingyuan Huang^{1

2}, Shengyu Yao^{1

2}, Cong Xing^{1

2}, Weixiao Liu³, Bin Zhang^{1

2}, Shiqing Feng^{1

2}

Affiliations

¹ Department of Orthopedics, Tianjin Medical University General Hospital, No.154 Anshan Road, Heping District, Tianjin, 300052, China.
² International Science and Technology Cooperation Base of Spinal Cord Injury, Tianjin Key Laboratory of Spine and Spinal Cord Injury,Department of Orthopedics, Tianjin Medical University General Hospital, Tianjin, China.
³ Department of Orthopedics, Kuancheng Manzu Autonomous Country Hospital, Chengde, China.

Abstract

Spinal cord injury (SCI) is one kind of severe diseases with high mortality and morbidity worldwide, and lacks effective therapeutic interventions currently, which leads to not only permanent neurological impairments but also heavy social and economic burden. Recent studies have proved that circRNAs are highly expressed in neural tissues, regulating the neuronal and synaptic functions. What's more, significantly altered circRNAs expression profiles are closely associated with the pathophysiology of SCI. In this review, we summarize the current advance on the role of circRNAs in SCI, which may provide a better understanding of pathogenesis and therapeutic strategies of SCI.

The translational potential of this article: The Translational potential of this article is that A further understanding of circRNAs in the pathogenesis of SCI will promote the circRNA-based clinical applications.

Keywords: CircRNAs; Nerve regeneration; Spinal cord injury.

Publication types

Review