A SHHecret target of relapsed medulloblastoma: Astrocytes

Zulekha A Qadeer; William A Weiss

doi:10.1084/jem.20211141

A SHHecret target of relapsed medulloblastoma: Astrocytes

J Exp Med. 2021 Sep 6;218(9):e20211141. doi: 10.1084/jem.20211141. Epub 2021 Aug 16.

Authors

Zulekha A Qadeer¹, William A Weiss^{1

2}

Affiliations

¹ Department of Neurology and Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA.
² Department of Pediatrics, Neurosurgery and Brain Tumor Research Center, University of California, San Francisco, San Francisco, CA.

Abstract

In this issue of JEM, Guo et al. (2021. J. Exp. Med.https://doi.org/10.1084/jem.20202350) examine the importance of tumor-derived astrocytes in SHH-medulloblastoma recurrence. They show that tumor cells transdifferentiate to tumor-derived astrocytes via bone morphogenetic proteins and Sox9, which excitingly can be targeted by BMP inhibitors.

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MeSH terms

Astrocytes
Brain Neoplasms*
Cerebellar Neoplasms*
Humans
Medulloblastoma*
Neoplasm Recurrence, Local