Abstract
SilE and SilB are both proteins involved in the silver efflux pump found in Gram-negative bacteria such as S. typhimurium. Using model peptides along with NMR and CD experiments, we show how SilE may store silver ions prior to delivery and we hypothesize for the first time the interplay between SilB and SilE.
MeSH terms
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Amino Acid Sequence
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Bacterial Proteins / chemistry
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Bacterial Proteins / metabolism*
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Binding Sites
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Carrier Proteins / chemistry
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Carrier Proteins / metabolism*
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Drug Resistance, Bacterial
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Nuclear Magnetic Resonance, Biomolecular
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Peptide Fragments / chemistry
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Peptide Fragments / metabolism*
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Protein Binding
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Salmonella typhimurium / chemistry
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Silver / metabolism*
Substances
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Bacterial Proteins
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Carrier Proteins
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Peptide Fragments
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SilE protein, Salmonella typhimurium
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Silver