The Role of Exosomes and Their Cargos in the Mechanism, Diagnosis, and Treatment of Atrial Fibrillation

Shengyuan Huang; Yating Deng; Jiaqi Xu; Jiachen Liu; Liming Liu; Chengming Fan

doi:10.3389/fcvm.2021.712828

The Role of Exosomes and Their Cargos in the Mechanism, Diagnosis, and Treatment of Atrial Fibrillation

Front Cardiovasc Med. 2021 Jul 28:8:712828. doi: 10.3389/fcvm.2021.712828. eCollection 2021.

Authors

Shengyuan Huang¹, Yating Deng², Jiaqi Xu³, Jiachen Liu², Liming Liu¹, Chengming Fan¹

Affiliations

¹ Department of Cardiovascular Surgery, The Second Xiangya Hospital, Central South University, Changsha, China.
² Xiangya Medical College of Central South University, Changsha, China.
³ Department of Spine Surgery and Orthopaedics, Xiangya Hospital, Central South University, Changsha, China.

Abstract

Atrial fibrillation (AF) is the most common persistent arrhythmia, but the mechanism of AF has not been fully elucidated, and existing approaches to diagnosis and treatment face limitations. Recently, exosomes have attracted considerable interest in AF research due to their high stability, specificity and cell-targeting ability. The aim of this review is to summarize recent literature, analyze the advantages and limitations of exosomes, and to provide new ideas for their use in understanding the mechanism and improving the diagnosis and treatment of AF.

Keywords: atrial fibrillation; biomarkers; exosomes; mechanism; non-coding RNA; treatment.

Publication types

Review