Recent Progress on NIR-II Photothermal Therapy

Yunguang Zhang; Siyu Zhang; Zihan Zhang; Lingling Ji; Jiamei Zhang; Qihao Wang; Tian Guo; Simin Ni; Ru Cai; Xiaoyu Mu; Wei Long; Hao Wang

doi:10.3389/fchem.2021.728066

Recent Progress on NIR-II Photothermal Therapy

Front Chem. 2021 Jul 29:9:728066. doi: 10.3389/fchem.2021.728066. eCollection 2021.

Authors

Yunguang Zhang¹, Siyu Zhang¹, Zihan Zhang¹, Lingling Ji¹, Jiamei Zhang¹, Qihao Wang¹, Tian Guo¹, Simin Ni¹, Ru Cai¹, Xiaoyu Mu², Wei Long³, Hao Wang²

Affiliations

¹ School of Science, Xi'an University of Posts and Telecommunications, Xi'an, China.
² Tianjin Key Laboratory of Brain Science and Neuroengineering, Academy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin, China.
³ Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China.

Abstract

Photothermal therapy is a very promising treatment method in the field of cancer therapy. The photothermal nanomaterials in near-infrared region (NIR-I, 750-900 nm) attracts extensive attention in recent years because of the good biological penetration of NIR light. However, the penetration depth is still not enough for solid tumors due to high tissue scattering. The light in the second near-infrared region (NIR-II, 1000-1700 nm) allows deeper tissue penetration, higher upper limit of radiation and greater tissue tolerance than that in the NIR-I, and it shows greater application potential in photothermal conversion. This review summarizes the photothermal properties of Au nanomaterials, two-dimensional materials, metal oxide sulfides and polymers in the NIR-II and their application prospects in photothermal therapy. It will arouse the interest of scientists in the field of cancer treatment as well as nanomedicine.

Keywords: NIR-II; cancer therapy; nanomaterials; photothermal conversion; photothermal therapy.

Publication types

Review