Does Non-Neurologic Multiorgan Dysfunction After Out-of-Hospital Cardiac Arrest among Children Admitted in Coma Predict Outcome 1 Year Later?

Kelly L Corbett; Angela P Presson; Chong Zhang; Yizhe Xu; Susan L Bratton; Rebecca R Dixon

doi:10.1055/s-0040-1715850

Does Non-Neurologic Multiorgan Dysfunction After Out-of-Hospital Cardiac Arrest among Children Admitted in Coma Predict Outcome 1 Year Later?

J Pediatr Intensive Care. 2021 Sep;10(3):188-196. doi: 10.1055/s-0040-1715850. Epub 2020 Sep 11.

Authors

Kelly L Corbett¹, Angela P Presson^{2

3}, Chong Zhang³, Yizhe Xu³, Susan L Bratton², Rebecca R Dixon⁴

Affiliations

¹ Department of Pediatrics, Section of Critical Care Medicine, Dartmouth-Hitchcock Medical Center, Lebanon.
² Department of Pediatrics, Division of Critical Care Medicine, University of Utah, Salt Lake City, Utah, United States.
³ Department of Internal Medicine, Division of Epidemiology, University of Utah, Salt Lake City, Utah, United States.
⁴ Department of Pediatrics, Washington Permanente Medical Group, Spokane, Washington, United States.

Abstract

In this article, we investigated whether non-neurologic multiorgan dysfunction syndrome (MODS) following out-of-hospital cardiac arrest (OHCA) predicts poor 12-month survival. We conducted a secondary data analysis of therapeutic hypothermia after pediatric cardiac arrest out-of-hospital randomized trial involving children who remained unconscious and intubated after OHCA ( n = 237). Associations between MODS and 12-month outcomes were assessed using multivariable logistic regression. Non-neurologic MODS was present in 95% of patients and sensitive (97%; 95% confidence interval [CI]: 93-99%) for 12-month survival but had poor specificity (10%; 95% CI: 4-21%). Development of non-neurologic MODS is not helpful to predict long-term neurologic outcome or survival after OHCA.

Keywords: cardiac arrest; multiorgan dysfunction syndrome; outcomes.

Abstract

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