The Real-World Practice of Fruquintinib for Chinese Patients with Metastatic Colorectal Cancer

Yan Song; Tao Qu; Honggang Zhang; Yongkun Sun; Chengxu Cui; Yihebali Chi; Wen Zhang; Xingyuan Wang; Lin Yang

doi:10.2147/CMAR.S313275

The Real-World Practice of Fruquintinib for Chinese Patients with Metastatic Colorectal Cancer

Cancer Manag Res. 2021 Aug 7:13:6199-6205. doi: 10.2147/CMAR.S313275. eCollection 2021.

Authors

Yan Song¹, Tao Qu¹, Honggang Zhang¹, Yongkun Sun¹, Chengxu Cui¹, Yihebali Chi¹, Wen Zhang¹, Xingyuan Wang¹, Lin Yang¹

Affiliation

¹ Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, People's Republic of China.

Abstract

Background: In FRESCO trial, a phase III study of fruquintinib demonstrated a significant improvement on the overall survival (OS) of patients with metastatic colorectal cancer (mCRC) who failed to response to available standard treatments. The aim of the current study was to evaluate the safety and effectiveness of fruquintinib in Chinese mCRC patients in the real-world setting.

Methods: Patients with mCRC treated with fruquintinib at our hospital were retrospectively reviewed. Patient demographics, treatment, adverse events and survival data were collected. OS and progression-free survival (PFS) were estimated using the Kaplan-Meier method.

Results: In total, 76 patients were evaluated from December 2018 to January 2020. The median (range) age was 59.5 (34-86) years, ECOG PS 0-1/2 was 86.8%/13.2%, and 38 (50%)/30 (39.5%) patients had experienced more than two prior therapies for mCRC. The median treatment duration was 3.6 cycles. Treatment-related adverse events (TRAEs) resulted in dose reduction were 17.1% of the patients without any treatment discontinuation. The most common grade 3 or 4 TRAEs were hypertension (9.2%), hand-foot skin reaction (7.9%), thrombocytopenia (3.9%), anaemia (2.6%), increased ALT (1.3%), oral mucositis (1.3%), proteinuria (1.3%) and neutropenia (1.3%). The median PFS was 5.1 months (95% CI 3.8-6.4 months), and the median OS was 12.0 months (95% CI 8.0-16.1 months). In patients with hypertension or hypothyroidism, a survival extension approximate to 6 months was observed, but the difference is not yet statistically significant. CEA decreased after fruquintinib treatment could be considered as a potential predictor for better OS.

Conclusion: The outcome of this real-life study was consistent with that of the randomised controlled trial. There were no new safety concerns. Future studies of fruquintinib should be conducted to identify patients who tend to obtain more benefits from fruquintinib alone or in combination with other agents.

Keywords: fruquintinib; metastatic colorectal cancer; real-world settings; toxicities.