Molecular docking analysis of vascular endothelial growth factor receptor with bioactive molecules from Piper longum as potential anti-cancer agents

Selvaraj Jayaraman; Vidhya Rekha Umapathy; Jayamathi Govindaraj; Keerthidaa Govidaraj

doi:10.6026/97320630017223

Molecular docking analysis of vascular endothelial growth factor receptor with bioactive molecules from Piper longum as potential anti-cancer agents

Bioinformation. 2021 Jan 31;17(1):223-228. doi: 10.6026/97320630017223. eCollection 2021.

Authors

Selvaraj Jayaraman¹, Vidhya Rekha Umapathy², Jayamathi Govindaraj³, Keerthidaa Govidaraj⁴

Affiliations

¹ Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai - 600 077, India.
² Department of Public Health Dentistry, Sree Balaji Dental College and Hospital, Pallikaranai,Chennai-600 100, India.
³ Department of Biochemistry, Sree Balaji Dental College and Hospital, Pallikaranai, Chennai-600 100, India.
⁴ MGM Health Care, Nelson Manickam Road, Chennai- 600029, India.

Abstract

It is known that vascular endothelial growth factor receptor (VGFR) is linked with cancer. Therefore, it is of interest to document the molecular binding features of bioactive molecules from Piper longum as potential anti-cancer agents with VGFR2 for further consideration. Thus, we document the binding features of four compounds (sesamin, fargesin, longamide and piperlonguminine) with VGFR2 for further consideration in drug discovery.

Keywords: Piper longum; VEGFR; lung cancer; molecular docking.