Although the Audit & Feedback (A&F) strategy is widely used in the healthcare context, a margin of uncertainty remains regarding the actual effectiveness in actually improving healthcare quality. Effectiveness research on A&F should be improved, without replicating studies and results already consolidated over the years. Comparative efficacy studies are needed in order to evaluate A&F strategies in poorly explored research areas, such as community care or home care. In these areas, a translational research framework has been developed by the Tuscan Regional Health Agency: its aim is to make the results available to the professionals involved in the territorial management of chronic patients. Doctors coordinating the territorial functional aggregations and referring community physicians are the main targets. A&F can also be a tool to improve the performance of general practitioners in their actions aimed at maintaining patients' adherence to clinical prescriptions, highlighting any significant difference between the monitored performances.