Angiogenic potential of mesenchymal stem cells derived from patients with diabetes seeded on decellularized micro fragments

Assaf Assis; Yechiel N Gellman; Avivit Cahn; Amir Haze; Sandra Camargo; Eduardo Mitrani

doi:10.1016/j.jdiacomp.2021.108001

Angiogenic potential of mesenchymal stem cells derived from patients with diabetes seeded on decellularized micro fragments

J Diabetes Complications. 2021 Oct;35(10):108001. doi: 10.1016/j.jdiacomp.2021.108001. Epub 2021 Aug 3.

Authors

Assaf Assis¹, Yechiel N Gellman², Avivit Cahn³, Amir Haze², Sandra Camargo¹, Eduardo Mitrani⁴

Affiliations

¹ Department of Cell and Developmental Biology, The Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel.
² Diabetic Foot Unit, Department of Orthopedics, Hadassah Medical Center, Jerusalem, Israel; The Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.
³ The Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel; Diabetes Unit, Department of Endocrinology and Metabolism, Hadassah Medical Center, Jerusalem, Israel.
⁴ Department of Cell and Developmental Biology, The Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel.. Electronic address: mitrani@vms.huji.ac.il.

PMID: 34391637
DOI: 10.1016/j.jdiacomp.2021.108001

Abstract

Mesenchymal stem cells (MSCs) are a potential source of angiogenic factors which may promote wound healing in poorly vascularized diabetic foot ulcers. We demonstrate that MSCs of patients with diabetic foot ulcers seeded on decellularized micro-fragments transcribe and secrete angiogenic factors in amounts comparable to MSCs derived from healthy individuals.

Keywords: Angiogenesis; Angiogenic factors; Diabetes; Mesenchymal stem cells; Tissue engineering.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Angiogenesis Inducing Agents / metabolism*
Diabetes Mellitus*
Diabetic Foot* / therapy
Humans
Mesenchymal Stem Cell Transplantation*
Mesenchymal Stem Cells* / cytology
Wound Healing

Substances

Angiogenesis Inducing Agents