Effectiveness of the BNT162b2 mRNA Covid-19 vaccine in Spanish healthcare workers

Concepción Núñez López; Juan Manuel González de Abreu; Verónica Pérez-Blanco; Rosa de Miguel Buckley; María Pilar Romero Gómez; Marta Díaz-Menéndez; La Paz Health Care Workers Vaccination Study Group; Appendix. La Paz Health Care Workers Vaccination Study Group

doi:10.1016/j.eimc.2021.06.021

Effectiveness of the BNT162b2 mRNA Covid-19 vaccine in Spanish healthcare workers

Enferm Infecc Microbiol Clin (Engl Ed). 2021 Jul 27:S0213-005X(21)00223-8. doi: 10.1016/j.eimc.2021.06.021. Online ahead of print.

[Article in English, Spanish]

Authors

Concepción Núñez López¹, Juan Manuel González de Abreu¹, Verónica Pérez-Blanco², Rosa de Miguel Buckley³, María Pilar Romero Gómez⁴, Marta Díaz-Menéndez⁵; La Paz Health Care Workers Vaccination Study Group; Appendix. La Paz Health Care Workers Vaccination Study Group

Collaborators

Concepción Núñez López⁶, Juan Manuel González⁶, Natalia Arizaga Lobeto⁶, Natalia Pérez Hidalgo⁶, Maria Castiñeiras Ortega⁶, Consuelo Rodrigo Garcia-Pando⁶, Verónica Pérez-Blanco⁷, Claudia García-Vaz⁷, Julio García Rodríguez⁸, María Pilar Romero Gómez⁸, Francisco Arnalich Fernández⁹, Rosa de Miguel Buckley¹⁰, Marta Díaz-Menéndez¹⁰, Jose R Arribas¹⁰

Affiliations

¹ Occupational Health Department, La Paz University Hospital, Madrid, Spain.
² Preventive Medicine Department, La Paz University Hospital, Madrid, Spain.
³ Infectious Disease Unit, Internal Medicine Department, La Paz University Hospital, Madrid, Spain.
⁴ Microbiology Department, La Paz University Hospital, Madrid, Spain.
⁵ Infectious Disease Unit, Internal Medicine Department, La Paz University Hospital, Madrid, Spain. Electronic address: marta.diaz@salud.madrid.org.
⁶ Occupational Health Department.
⁷ Preventive Medicine Department.
⁸ Microbiology Department.
⁹ Internal Medicine Department.
¹⁰ Infectious Disease Unit.

PMID: 34391596
DOI: 10.1016/j.eimc.2021.06.021

Abstract

Introduction: Frontline health care workers (HCW) have higher risk than the general population to become infected by SARS.CoV.2, so they were a priority group for Covid-19 vaccine administration. We compared the incidence and prevalence of HCW infected pre-and post-vaccination with the BNT162b2 mRNA COVID-19 vaccine.

Material and methods: Prospective observational study carried out between 01/12/20 and 07/03/21 in La Paz University Hospital, Madrid (Spain). SARS.CoV.2 positive cases in HCW after vaccination were collected and compared to those hospitalized COVID-19 patients at the same hospital.

Results: Two weeks after finishing the first round of vaccinations daily new cases of HCW infections (symptomatic and asymptomatic) decreased substantially and cumulative cases of infected HCW and hospitalized COVID-19 patients started to diverge. No new positive cases of HCW infection were registered seven days after the second dose of BNT162b2 mRNA COVID-19 vaccine.

Conclusions: BNT162b2 mRNA COVID-19 vaccine is highly effective in Spanish HCW.

Keywords: COVID; Healthcare workers; SARS-COV2; SARS-CoV2; Trabajadores sanitarios; Vaccine; Vacuna.