Zooming in on T cell clones: Are we heading to personalized treatment of allergy?

Sci Immunol. 2021 Aug 13;6(62):eabj1366. doi: 10.1126/sciimmunol.abj1366.

Authors

Netali Ben-Baruch Morgenstern¹, Mark Rochman¹, Marc E Rothenberg²

Affiliations

¹ Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, 3333 Burnet Ave., Cincinnati, OH 45229, USA.
² Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, 3333 Burnet Ave., Cincinnati, OH 45229, USA. rothenberg@cchmc.org.

PMID: 34389614
DOI: 10.1126/sciimmunol.abj1366

Abstract

Single-cell RNA and TCR sequencing of peripheral blood and esophageal cells of human eosinophilic esophagitis uncovers antigen-restricted T_H2 cells.

Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

Publication types

Review
Comment

MeSH terms

Clone Cells
Eosinophilic Esophagitis*
Gastritis*
Humans
Precision Medicine
T-Lymphocytes